Use of High CPAP (≥9 cmH2O) is becoming increasingly common, often as an alternative to NIPPV. While previous research has shown that NIPPV may be superior to regular CPAP (8 cmH2O), there are virtually no data comparing High CPAP pressures with NIPPV.

 

NOVEL is the first multi-centre clinical trial that is comparing High CPAP vs. NIPPV among babies who are either:

1. No longer oxygenating/ventilation on CPAP 8 cmH2O

2. Are being extubated from mean airway pressure ≥10 cmH2O

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As a pilot study, the primary outcome is feasibility of recruitment of patients into the study, but our main secondary outcome is failure of assigned mode within 7 days. Our target sample size is 100 patients across 3 centres (McMaster University, University of Alberta, and University of California-Davis)

 

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ClinicalTrials.gov registration number: NCT03512158

​Non-invasive Respiratory Support in Preterm Infants - Full Text View - ClinicalTrials.gov

Link to Publication:  https://pubmed.ncbi.nlm.nih.gov/36787974/