There are very little published data on the optimal settings - both prior to and following extubation that optimize success of extubation and improve outcomes. We sought to evaluate the published literature to summarize available data in preterm neonates in this regard.

​

We summarized available data on published patient-level pre- and post-extubation pressures and settings on all modes. Secondly, we meta-analysed (put together) data from studies that have compared higher vs. lower pressures and found limited data that suggests that higher pressures may reduce risk of extubation failure. However, these findings need confirmation in future studies to find the optimal peri-exubation settings. 

​

​

Link to publication: https://pubmed.ncbi.nlm.nih.gov/38216677/